A risk assessment study of SARS-CoV-2 propagation in the manufacturing of cellular productsReview Published on 2023-02-012023-07-10 Journal: Regenerative Medicine [Category] COVID19(2023년), [키워드] ACE2 Cell therapy Compliance COVID-19 Gene therapy manufacturing Propagation risk assessment. SARS-CoV-2 TMPRSS2 [DOI] 10.2217/rme-2022-0096 PMC 바로가기 [Article Type] Review
The expression profile of 79 genes from 107 viruses revealed new insights into disease susceptibility in rats, mice, and muskratsArticle Published on 2023-01-012023-06-22 Journal: Physiological Genomics [Category] 조류인플루엔자, [키워드] ACE2 COVID-19 SARS-CoV-2 TMPRSS2 TMPRSS4. [DOI] 10.1152/physiolgenomics.00141.2022 PMC 바로가기
BC-11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS-CoV-2 host cell entryArticle Published on 2023-01-012023-07-10 Journal: Archiv der Pharmazie [Category] COVID19(2023년), [키워드] BC-11 CovPDB SARS-CoV-2 cell entry targeted covalent inhibitor. TMPRSS2 [DOI] 10.1002/ardp.202200371 PMC 바로가기
Generation of Angiotensin-Converting Enzyme 2/Transmembrane Protease Serine 2-Double-Positive Human Induced Pluripotent Stem Cell-Derived Spheroids for Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Drug EvaluationArticle Published on 2022-12-212023-07-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), [키워드] COVID-19 hACE2 hiPSC-derived spheroids in vitro drug evaluation. SARS-CoV-2 TMPRSS2 [DOI] 10.1128/spectrum.03490-22 PMC 바로가기
Use of Antiandrogens as Therapeutic Agents in COVID-19 PatientsReview Published on 2022-12-072023-07-11 Journal: Viruses [Category] COVID19(2023년), [키워드] ACE2 androgens antiandrogens coronavirus SARS-CoV-2 sex hormones. TMPRSS2 [DOI] 10.3390/v14122728 PMC 바로가기 [Article Type] Review
Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA.1 and BA.2Article Published on 2022-12-012022-11-16 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] change changes in Characteristics circulating cleavage contribute contributing to demonstrated dependent on determinant endosomal entry endosomal entry pathway endosomal pathway Entry facilitate feature Fusogenicity H655Y identify increase investigated less Mutation omicron Omicron BA.1 and BA.2 Pathogenesis pathogenicity plasma membrane predominant Proteases recent reduce reduced retained SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 WT serine protease spike spike mutation Spike protein spike protein cleavage. subsequent the spike protein TMPRSS2 transmembrane serine protease Virological virus entry [DOI] 10.1080/22221751.2022.2117098 PMC 바로가기
Lower serum alpha 1 antitrypsin levels in patients with severe COVID-19 compared with patients hospitalized due to non-COVID-19 pneumoniaObservational Study Published on 2022-12-012023-07-10 Journal: Infectious diseases (London, England) [Category] COVID19(2023년), [키워드] A1AT alpha-1 antitrypsin COVID-19 pneumonia. SARS-CoV-2 TMPRSS2 [DOI] 10.1080/23744235.2022.2111464 PMC 바로가기 [Article Type] Observational Study
Transmembrane serine protease TMPRSS2 implicated in SARS-CoV-2 infection is autoactivated intracellularly and requires N-glycosylation for regulationArticle Published on 2022-12-012023-07-10 Journal: The Journal of Biological Chemistry [Category] COVID19(2023년), [키워드] HAI-1 HAI-2 N-glycosylation SARS-CoV-2 Spike protein TMPRSS2 TTSP zymogen activation. [DOI] 10.1016/j.jbc.2022.102643 PMC 바로가기
SARS-CoV-2 infection and replication kinetics in different human cell types: The role of autophagy, cellular metabolism and ACE2 expressionArticle Published on 2022-11-012022-11-16 Journal: Life sciences [Category] SARS, 유전자 메커니즘, [키워드] A549 ACE2 ACE2 expression angiotensin ATP synthase autophagy BEAS-2B Brain Caco-2 can be used Cell cell line cell lines cellular cellular metabolism COVID-19 COX endothelial energy metabolism evaluated expression level HEK-293 human cell human cell line in vitro intestine intrinsically investigated kidney liver mechanism metabolism Mitochondria mitochondrial metabolism modified cell line molecular mechanism mRNA expression NDUFS2 overexpressed overexpressing overexpression Protein Replication replication kinetics respiratory tract RT-qPCR SARS-COV-2 infection SARS-CoV-2 replication SH-SY5Y susceptibility susceptible cell TMPRSS2 TMPRSS2 expression TMPRSS2. uninfected cell various tissue viral infection Viral load viral replication were assessed western blot [DOI] 10.1016/j.lfs.2022.120930 PMC 바로가기
Towards Covid-19 TMPRSS2 enzyme inhibitors and antimicrobial agents: Synthesis, antimicrobial potency, molecular docking, and drug-likeness prediction of thiadiazole-triazole hybridsResearch article Published on 2022-11-012022-10-05 Journal: Journal of Molecular Structure [Category] 치료제, [키워드] 1 2 3 3-Triazoles 4-Thiadiazole analogue antimicrobial activity Bacillus subtilis binding affinity Candida albican candidate chalcone chloride Compound COVID-19 drug-likeness enzyme Escherichia coli exhibited FIVE Hydrazonoyl halides identify in silico in vitro inhibitor molecular docking pathogen Prevent proliferation Pseudomonas aeruginosa screened Staphylococcus aureus submitted synthesis synthesised therapeutic activity TMPRSS2 TMPRSS2 enzyme transmembrane serine protease Treatment Vanillin was tested [DOI] 10.1016/j.molstruc.2022.133659 [Article Type] Research article